Interactions between functional groups in protein-nucleic acid associations

Protein–nucleic acid interactions

Thermodynamic Database for Protein-Nucleic Acid Interactions

Protein-nucleic acid interaction plays an essential role in the regulation of gene expression. Structural and binding information provides insight into the mechanism of protein-nucleic acid recognition. Although there are structural databases for protein-nucleic acid complexes, there exists no database for protein-nucleic acid binding. Thus, we have decided to develop the Thermodynamic Database...

MS04 Protein-protein and Protein-Nucleic acid interactions

24 European Crystallographic Meeting, ECM24, Marrakech, 2007 Page s132 Acta Cryst. (2007). A63, s132 MS04 P14 Preparation and crystallization of rat natural killer cell receptor NKR-P1B Ondrej Vanek, Petr Kolenko, Vladimir Kopecky, Jr., Jan Dohnalek, Karel Bezouska Department of Biochemistry, Faculty of Science, Charles University in Prague, Hlavova 2030,CZ-12840 Prague, Czech Republic. Institu...

Metal/Nucleic-Acid Interactions

Protein-Nucleic Acid Interactions in Nuclease and Polymerases

DNA polymerase binds to the double stranded DNA and extends the primer strand by adding deoxyribonucletide to the 3’-end. Several reactions in the polymerase active site have been reported by Kornberg in addition to the polymerization. We observed DNA polymerase I can act as a pyrophosphatase and hydrolyze deoxyribonucletide. In performing the pyrophosphatase activity, DNA polymerase I requires...